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Genetic analysis of enhancer of split gene function in regulating cell fate commitment in Drosophila development

Reference	CAD05662
Principal Investigator / Supervisor	Dr Frederick Tata
Co-Investigators / Co-Supervisors
Institution	University of Leicester
Department	Genetics
Funding type	Research
Value (£)	178,630
Status	Completed
Type	Research Grant
Start date	11/11/1996
End date	11/11/1999
Duration	36 months

Abstract

I have shown that targeted misexpression of individual bHLH genes from the Drosophila neurogenic gene complex Enhancer of split [E(spl)] represses cell fate determination. We wish to exploit this system to further define E(spl) bHLH gene function in controlling cell fate commitment. We will target misexpression in the embroyonic mesoderm to test the effect on myogenesis and define the aetiology of the phenotypes. We will use E(spl)bHLH misexpression as the basis of a genetic screen to identify genes that function with E(spl) in repressing the neural fate. We will test in vivo the requirement for groucho in mediating E(spl) function. We will clone E(spl)-related genes from the housefly to compare number, sequence, expression and organisation.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Commitment and Determination (CAD) [1995]
Funding Scheme	X – not Funded via a specific Funding Scheme

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