Award details

Action of curly leaf and interacting genes in maintaining patterns of homeotic gene expression in Arabidopsis

Reference	CAD05650
Principal Investigator / Supervisor	Dr Justin Goodrich
Co-Investigators / Co-Supervisors
Institution	University of Edinburgh
Department	Inst of Cell and Molecular Biology
Funding type	Research
Value (£)	150,646
Status	Completed
Type	Research Grant
Start date	18/08/1996
End date	18/08/1999
Duration	36 months

Abstract

The Polycomb-group (Pc-G) genes promote commitment in Drosophila by locking into place early patterns of homeotic gene expression. We recently identified an Arabidopsis Pc-G gene ,CURLY LEAF (CLF), which is required for stable repression of the homeotic gene AGAMOUS (AG) during leaf and flower development. I propose to define the action of CLF and related genes in the maintenance of homeotic gene expression patterns by (1) constructing genetic mosaics in order to identify the time at which CLF is required to repress AG (2) characterisation of a second locus conferring a similar phenotype (3) analysing the effect of gain of function alleles and CLF over expression and (4) by genetic and molecular screens to isolate other genes that interact with CLF.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Commitment and Determination (CAD) [1995]
Funding Scheme	X – not Funded via a specific Funding Scheme

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