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Cellular signalling events associated with lineage restriction in bipotent neutrophil macrophage progenitor cells
Reference
CAD05566
Principal Investigator / Supervisor
Professor Anthony David Whetton
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
158,106
Status
Completed
Type
Research Grant
Start date
01/08/1996
End date
13/01/2000
Duration
41 months
Abstract
The object of this proposal is to study receptor-mediated lineage restriction in primitive haemopoietic cells. To do this we will use a well characterised population of enriched bipotent neutrophil macrophage progenitor cells and study the cellular signalling events stimulated by SCF (which promotes neutrophilic development) and M-CSF (macrophage development). SCF and M-CSF bind to related protein tyrosine kinases and we will analyse the proteins which associate with and are activated by these receptors upon ligand binding. Signalling proteins activated by only one of these cytokines will be further investigated for their ability to potentiate lineage determination.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Commitment and Determination (CAD) [1995]
Funding Scheme
X – not Funded via a specific Funding Scheme
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