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Cellular signalling events associated with lineage restriction in bipotent neutrophil macrophage progenitor cells

ReferenceCAD05566
Principal Investigator / Supervisor Professor Anthony David Whetton
Co-Investigators /
Co-Supervisors
Institution The University of Manchester
DepartmentLife Sciences
Funding typeResearch
Value (£) 158,106
StatusCompleted
TypeResearch Grant
Start date 01/08/1996
End date 13/01/2000
Duration41 months

Abstract

The object of this proposal is to study receptor-mediated lineage restriction in primitive haemopoietic cells. To do this we will use a well characterised population of enriched bipotent neutrophil macrophage progenitor cells and study the cellular signalling events stimulated by SCF (which promotes neutrophilic development) and M-CSF (macrophage development). SCF and M-CSF bind to related protein tyrosine kinases and we will analyse the proteins which associate with and are activated by these receptors upon ligand binding. Signalling proteins activated by only one of these cytokines will be further investigated for their ability to potentiate lineage determination.

Summary

unavailable
Committee Closed Committee - Genes & Developmental Biology (GDB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Commitment and Determination (CAD) [1995]
Funding SchemeX – not Funded via a specific Funding Scheme
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