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The molecular control of neuronal phenotype in the developing spinal chord
Reference
CAD04409
Principal Investigator / Supervisor
Professor Stephen Hunt
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Molecular Neurobiology Unit
Funding type
Research
Value (£)
121,308
Status
Completed
Type
Research Grant
Start date
30/10/1995
End date
30/10/1998
Duration
36 months
Abstract
The degree to which neuronal phenotype in the developing spinal cord is progressively restricted by environmental signals is poorly understood. We will investigate this problem with targeted deletions of the NK1, c-jun and c-fos genes in mice. Each of these genes has been implicated in aspects of neuronal development: NK1 in dorsoventral patterning of the neural tube and axon guidance; c-jun in motorneurone neurogenesis and c-fos in programmed cell death. Embryos will be analysed using immunohistochemistry, in situ hybridisation and dye tracing techniques and in vivo approaches will be complemented by in vitro analysis using spinal cord explants in collagen gels and roller culture of postimplantation embryos.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Commitment and Determination (CAD) [1995]
Funding Scheme
X – not Funded via a specific Funding Scheme
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