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The determination of tissue-specific antibiotic production in Streptomyces coelicolor A3(2)
Reference
CAD04400
Principal Investigator / Supervisor
Professor Mervyn Bibb
Co-Investigators /
Co-Supervisors
Institution
John Innes Centre
Department
John Innes Centre Department
Funding type
Research
Value (£)
120,858
Status
Completed
Type
Research Grant
Start date
01/01/1996
End date
01/05/1999
Duration
40 months
Abstract
Streptomycetes produce highly differentiated colonies consisting of a branched network of vegetative substrate mycelium and specialised aerial hyphae that ultimately differentiate into spores. They produce a wide variety of medically and agriculturally important antibiotics in a growth phase-dependent and tissue-specific manner, with antibiotic production limited to the substrate mycelium. We have identified a small diffusible signalling molecule (probably a gamma-butyrolactone) in culture supermatants of transition phase cultures of Streptomcyes coelicolor A3(2) that elicits the precocious production of actinorhodin, one of at least four antibiotics made by the wild-type strain. We wish to determine the mechanism whereby this small molecule commits the substrate, but not aerial, hyphae to antibiotic production.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Commitment and Determination (CAD) [1995]
Funding Scheme
X – not Funded via a specific Funding Scheme
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