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The role of transcription factors in the regulation of haemopoietic commitment
Reference
CAD04378
Principal Investigator / Supervisor
Dr Michael Cross
Co-Investigators /
Co-Supervisors
Professor T Dexter
,
Dr Clare Heyworth
Institution
The University of Manchester
Department
Experimental Haematology
Funding type
Research
Value (£)
124,084
Status
Completed
Type
Research Grant
Start date
06/11/1995
End date
06/11/1998
Duration
36 months
Abstract
The production of mature effector cells from mulitpotent haemopoietic progenitors involves strict regulation of cell survival, proliferation and lineage commitment. A number of transcription factors are known to influence haemopoiesis, but little is known of their precise roles in governing individual processes. Using a novel combination of recently developed techniques, the precise roles of defined transcriptional factors will be determined by analysis of the fate of a single, multipotent progenitor cells in which transcription factor gene expression has been transiently manipulated.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Commitment and Determination (CAD) [1995]
Funding Scheme
X – not Funded via a specific Funding Scheme
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