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Histone acetylation and imprinting in early mouse development
Reference
CAD04371
Principal Investigator / Supervisor
Professor Bryan Turner
Co-Investigators /
Co-Supervisors
Professor Anne Ferguson-Smith
Institution
University of Birmingham
Department
Medical Sciences - Medicine
Funding type
Research
Value (£)
148,584
Status
Completed
Type
Research Grant
Start date
01/07/1995
End date
01/01/1999
Duration
42 months
Abstract
A novel immunoprecipitation technique by which chromatin fragments can be fractionated on the basis of acetylated histone H4 isoforms they contain, will be used to determine patterns of histone acetylation along imprinted and non-imprinted genes in preimplantation mouse embryos. We will define changes that occur in these patterns and development progresses. By comparing patterns of acetylation along imprinted genes, specifically Igf2, H19 and Xist, in normal and parthenogenetic embryos and cultured cells derived from embryos that are bimaternal and bipaternal for selected regions of the genome, we will define the role of histone (initially H4) acetylation in establishing and maintaining parental imprints.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Commitment and Determination (CAD) [1995]
Funding Scheme
X – not Funded via a specific Funding Scheme
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