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Study of cell fate specification in the early Caenorhabditis elegans embryo using pes-1 gene expression as a differentiation marker
Reference
CAD04370
Principal Investigator / Supervisor
Professor Ian Hope
Co-Investigators /
Co-Supervisors
Institution
University of Leeds
Department
Human Biology
Funding type
Research
Value (£)
111,450
Status
Completed
Type
Research Grant
Start date
01/10/1995
End date
31/12/1998
Duration
39 months
Abstract
Developmental inductions, of considerable importance in vertebrate development, are now known to have a central role in C. elegans embryogenesis. glp-1 encodes a cell-surface protein with extracellular epidermal growth factor (EGF) like repeats and is the receptor for at least two of the main inductive signals in the early C. elegans embryo. Expression of the pes- 1 gene is glp-1 dependent. The glp-1 dependent induction of pes-1 will be fully characterised and other components of the glp-1/pes-1 induction pathway will be identified. In this way, the developmental processes by which cell fates are directed upon receipt of intercellular signals in C. elegans, and probably in other animal species, will be investigated.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Commitment and Determination (CAD) [1995]
Funding Scheme
X – not Funded via a specific Funding Scheme
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