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Control of mother cell commitment in Bacillus subtilis

Reference	CAD04345
Principal Investigator / Supervisor	Professor Jeffery Errington
Co-Investigators / Co-Supervisors
Institution	University of Oxford
Department	Sir William Dunn Sch of Pathology
Funding type	Research
Value (£)	151,058
Status	Completed
Type	Research Grant
Start date	01/10/1995
End date	01/10/1998
Duration	36 months

Abstract

Sporulation of the gram positive bacterium Bacillus subtilis begins with an asymmetric cell division that produces a prespore cell and a mother cell, which differentiate. The mother cell makes a major contribution to the development of the prespore but it is terminally differentiated, in that ultimately it lyses to release the mature spore. We have shown previously (grant AT43/543), that mother cell determination occurs soon after asymmetric division, probably as a result of the activation of the 0 transcription factor. Furthermore, we have isolated several classes of ccd mutations that perturb commitment to cell death. We propose to clone and characterise the ccd genes to elucidate the molecular basis for mother cell commitment.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Commitment and Determination (CAD) [1995]
Funding Scheme	X – not Funded via a specific Funding Scheme

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