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Investigation of local induction as a mechanism of recruitment of Drosophila neural precursors
Reference
CAD04339
Principal Investigator / Supervisor
Professor Andrew Jarman
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Inst of Cell and Molecular Biology
Funding type
Research
Value (£)
148,825
Status
Completed
Type
Research Grant
Start date
01/02/1996
End date
01/02/1999
Duration
36 months
Abstract
Certain sensory neurons in the Drosophila peripheral nervous system occur in aggregates. We have proposed that this results from homoiogenetic neural induction during development; i.e. founding neural precursors of these sensory neurons have the ability to recruit further neural precursors from the surrounding ectoderm. We shall obtain evidence for this primarily by genetic mosaic analysis of the proneural gene involved in selection of the founding precursors. We shall also determine whether the Drosophila EGF-receptor pathway is responsible for the intercellular signalling during this inductive process. This will be achieved by analysis of gene expression patterns, mutant phenotypes, and effects of experimental misexpression.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Commitment and Determination (CAD) [1995]
Funding Scheme
X – not Funded via a specific Funding Scheme
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