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Cytokine receptor function in ES cell self-renewal and commitment

Reference	CAD04329
Principal Investigator / Supervisor	Professor Austin Smith
Co-Investigators / Co-Supervisors	Professor Ian Chambers
Institution	University of Edinburgh
Department	Inst of Stem Cell Research
Funding type	Research
Value (£)	150,708
Status	Completed
Type	Research Grant
Start date	01/10/1995
End date	01/10/1998
Duration	36 months

Abstract

Propagation of the pluripotential phenotype of mouse embryonic stem (ES) cells is dependent on the cytokine LIF. This investigation will define in cellular and molecular terms the contribution(s) of LIF-receptor signalling to ES cell self-renewal. First, the temporal relationship between loss of self renewal ability (commitment) and LIF receptor activity will be established. Secondly, the essential signalling domains of LIF-receptor will be determined by complementation and their respective contributions to the self-renewal process delineated. Thirdly, the requirement for down-regulation of LIF-receptor activity during differentiation in vivo will be evaluated by misexpression studies.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Commitment and Determination (CAD) [1995]
Funding Scheme	X – not Funded via a specific Funding Scheme

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