Award details

Regulation of cell fate commitment

Reference	CAD04300
Principal Investigator / Supervisor	Dr Martin Baron
Co-Investigators / Co-Supervisors
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	175,045
Status	Completed
Type	Research Grant
Start date	01/11/1995
End date	01/11/1998
Duration	36 months

Abstract

During the development of multicellular organisms, cell to cell communication is required for cells to make developmental choices. A signal transmitted by the Notch membrane protein controls cell fate decisions and the timing of when a cell is competent to commit. Notch is widely distributed from Drosophila to humans. Drosophila genetics shows the level of activity on the Notch signal is crucial for determining cell fate decisions. One way the signal may be modulated is by the action of Suppressor of deltex (Su(dx)), whose wild type activity seems to repress the Notch signal. Su(dx) will be cloned, its in vivo function analysed. A genetic screen will identify genes that cooperate with Su(dx) in controlling Notch activity.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Commitment and Determination (CAD) [1995]
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search