BBSRC Portfolio Analyser
Award details
Role of protein S-thiolation as an antioxdant defence in yeast
Reference
C20436
Principal Investigator / Supervisor
Professor Christopher Grant
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
199,313
Status
Completed
Type
Research Grant
Start date
23/10/2003
End date
22/10/2006
Duration
36 months
Abstract
Protein-SH groups are amongst the most easily oxidized residues in proteins, and oxidation can result in intermolecular protein cross-linking and enzyme inactivation eventually leading to cell death. Irreversible oxidation can be prevented by protein S-thiolation, in which protein-SH groups form mixed disulphides with various low molecular weight thiols such as glutathione. The aim of this research project is to characterise the role of protein S-thiolation as an antioxidant defence in protection against conditions of oxidative stress. In particular, we will examine the control of this protein modification and determine its role in regulating cellular metabolism during both normal and stress conditions.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search