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The role of ribosomal proteins in protein targeting and translocation at the Endoplasmic Reticulum
Reference
C20431
Principal Investigator / Supervisor
Dr Martin Pool
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
178,104
Status
Completed
Type
Research Grant
Start date
04/04/2005
End date
03/04/2008
Duration
36 months
Abstract
The aim of this work is to understand the role of the ribosome in the targeting and translocation of secretory and membrane proteins to the endoplasmic reticulum. Recent data implicate ribosomal proteins L23a and L35 in making multiple interactions with the targeting/translocation machinery. We will select for mutants of these proteins in yeast that cause specific defects in translocation. A range of biochemical assays will be used to dissect the molecular basis for these defects both in yeast and with the analogous mutants in mammalian cells. Our ultimate aim is to define which elements of these proteins interact with which components of the translocation machinery and how they allow the ribosome to regulate protein translocation.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
Microbiology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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