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The role of the CD2v protein in evasion of host defence systems by African swine fever virus

ReferenceC20368
Principal Investigator / Supervisor Dr Linda Dixon
Co-Investigators /
Co-Supervisors
Institution The Pirbright Institute
DepartmentDiv of Microbiology Pirbright
Funding typeResearch
Value (£) 164,195
StatusCompleted
TypeResearch Grant
Start date 10/05/2004
End date 09/02/2007
Duration33 months

Abstract

African swine fever virus replicates in macrophages and encodes genes which modulate their function contributing to immune evasion and disease pathogenesis. Expression of the ASFV CD2v protein is ASFV infected macrophages causes inhibition of bystander lymphocyte proliferation. We will investigate how the CD2v protein functions and its effects on virus infected macrophages and bystander lymphocytes. We will determine if the extracellular or cytoplasmic domain of the protein is required to inhibit lymphocyte proliferation. CD2v cytoplasmic tail binds to a novel adaptor protein, SH3P7, which has roles in protein trafficking and signalling pathways. We will study the effect of CD2v on SH3P7 function.

Summary

unavailable
Committee Closed Committee - Biochemistry & Cell Biology (BCB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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