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The role of the CD2v protein in evasion of host defence systems by African swine fever virus
Reference
C20368
Principal Investigator / Supervisor
Dr Linda Dixon
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Microbiology Pirbright
Funding type
Research
Value (£)
164,195
Status
Completed
Type
Research Grant
Start date
10/05/2004
End date
09/02/2007
Duration
33 months
Abstract
African swine fever virus replicates in macrophages and encodes genes which modulate their function contributing to immune evasion and disease pathogenesis. Expression of the ASFV CD2v protein is ASFV infected macrophages causes inhibition of bystander lymphocyte proliferation. We will investigate how the CD2v protein functions and its effects on virus infected macrophages and bystander lymphocytes. We will determine if the extracellular or cytoplasmic domain of the protein is required to inhibit lymphocyte proliferation. CD2v cytoplasmic tail binds to a novel adaptor protein, SH3P7, which has roles in protein trafficking and signalling pathways. We will study the effect of CD2v on SH3P7 function.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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