Award details

Characterisation of connexin mediated communication in the control of stem cell differentiation

Reference	C20349
Principal Investigator / Supervisor	Professor Ian Mackenzie
Co-Investigators / Co-Supervisors	Dr Patricia Martin
Institution	Queen Mary University of London
Department	Sch of Medicine & Dentistry
Funding type	Research
Value (£)	216,547
Status	Completed
Type	Research Grant
Start date	01/03/2004
End date	28/02/2007
Duration	36 months

Abstract

The proposal focuses on determining the role of connexin mediated intercellular communication in mediating the dynamic process of somatic stem cell differentiation. Spatio-temporal patterns of cellular processes will be characterised by time-lapse microscopy and mapped together with regionally differing connexin profiles. The nature of molecule transfer will provide the zonal variation of gap junction and hemichannel functionality correlated with protein localisation. Approaches for blocking or augmenting communication with novel agents will be employed to manipulate cell commitment. The underlying aim is to elucidate the critical mechanisms involved to develop methods and therapeutics for the amplification of somatic stem cells.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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