BBSRC Portfolio Analyser
Award details
The role of Trichinella excreted/secreted proteins in parasite-induced de-differentiation of mammalian skeletal muscle
Reference
C20267
Principal Investigator / Supervisor
Professor Bernadette Connolly
Co-Investigators /
Co-Supervisors
Institution
University of Aberdeen
Department
School of Medical Sciences
Funding type
Research
Value (£)
236,051
Status
Completed
Type
Research Grant
Start date
05/01/2004
End date
04/01/2007
Duration
36 months
Abstract
Terminal differentiation of mammalian skeletal muscle cells is thought of as irreversible. Recent work suggests that these cells are capable of de-differentiating, although the underlying molecular mechanism is not understood. Trichinella spiralis, a parasitic nematode of mammalian skeletal muscle, offers a unique opportunity to study this process. T. spiralis infection leads to in vivo reversal of differentiation and subsequent re-programming to a new cell type. Proteins that modify host cell fate must be either exposed on the surface of the parasite or secreted into the host cytoplasm. We will use a proteomic approach to identify proteins secreted by T .spiralis and analyse their role in regulating de-differentiation in skeletal muscle.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search