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Elucidation of intracellular signalling pathways contributing to IGF receptor-specific regulation of gene expression
Reference
C20109
Principal Investigator / Supervisor
Professor Kenneth Siddle
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Clinical Biochemistry
Funding type
Research
Value (£)
200,273
Status
Completed
Type
Research Grant
Start date
10/03/2004
End date
09/03/2007
Duration
36 months
Abstract
The insulin-like growth factor (IGF) receptor acts to promote mitogenesis, inhibit apoptosis and induce differentiation, in part by regulating gene transcription. We have identified genes that are regulated by the IGF receptor but not the very closely regulated insulin receptor, and the aim of the project is to elucidate signalling pathways responsible for this differential regulation. By using chimeric and mutant receptors we will identify sequences within the IGFR required for specific regulation of gene expression and identify proteins interacting with these sequences. We will determine whether receptor-specific effects arise from differential activation of known signalling pathways or recruitment of novel signalling components.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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