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Heme delivery to and from the novel CcmE protein of a bacterial and plant c-type cytochrome biogenesis apparatus
Reference
C20071
Principal Investigator / Supervisor
Professor Stuart John Ferguson
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Biochemistry
Funding type
Research
Value (£)
235,255
Status
Completed
Type
Research Grant
Start date
01/02/2004
End date
31/01/2007
Duration
36 months
Abstract
Eight Ccm proteins catalyse the attachment of heme to polypeptide so as to generate a c-type cytochrome in plant mitochondria and many Gram negative bacteria. We will build on our recent success in achieving some of the Ccm-mediated steps in vitro by introducing new in vitro and in vivo strategies to elucidate the mechanism of the Ccm system in E. coli. Particular emphasis will be placed on heme provision, interactions between the Ccm proteins and apocytochromes, as well as studies of disulfide formation and reduction in the CXXCH motif of apocytochromes.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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