Award details

The roles of MT-MMPs in Angiogenesis

Reference	C20059
Principal Investigator / Supervisor	Professor Dylan Richard Edwards
Co-Investigators / Co-Supervisors	Professor Vincent Ellis, Dr Jelena Gavrilovic, Dr Caroline Pennington
Institution	University of East Anglia
Department	Biological Sciences
Funding type	Research
Value (£)	224,459
Status	Completed
Type	Research Grant
Start date	01/10/2003
End date	30/06/2007
Duration	45 months

Abstract

Using a 3-D endothelial tubulogenesis assay in fibrin gels as a model of angiogenesis, we have shown a dependence on membrane-type matrix metalloproteinase (MT-MMP) function. This proposal will explore the roles of MT-MMPs in angiogenesis by immunolocalisation and analysis of effects of adenoviral delivery of MT-MMPs and RNA interference constructs. We will also explore links between MT-MMPs and integrins. The proposal will use human endothelial calls and cells isolated from MT1-MMP-null mice. We will test the hypotheses that: 1) MT-MMPs act in a tissue-specific fashion to facilitate angiogenesis; 2) Selective targeting of MT-MMPs is a viable anti-angiogenic strategy; and 3) MT-MMP actions regulate or are functionally dependent on integrins. The proposal will shed light on the functions of this important class of cell surface proteins and generate new research tools.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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