Award details

Exploitation of host cells by Burkholderia pseudomallei

Reference	C20021
Principal Investigator / Supervisor	Dr Edouard Galyov
Co-Investigators / Co-Supervisors	Professor Mark Stevens
Institution	The Pirbright Institute
Department	Div of Molecular Biology Pirbright
Funding type	Research
Value (£)	180,587
Status	Completed
Type	Research Grant
Start date	02/02/2004
End date	01/10/2007
Duration	44 months

Abstract

Burkholderia pseudomallei, a facultative intracellular bacterium that causes melioidosis, has evolved novel strategies to subvert eukaryotic call functions. The bacteria promote their uptake by non-phagocytic cells, escape from endocytic vesicles, and are propelled within cells and from cell-to-cell by polar nucleation of actin. Uniquely, B. pseudomallei also induces cell fusion. We will assess the role of B. pseudomallei type III and type V secreted proteins in these processes and identify bacterial and cellular factors involved in actin-based motility. By studying B. pseudomallei-host cell interactions we will add to the understanding of the intracellular trafficking and survival of bacterial pathogens and the cellular processes they exploit.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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