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Defining a 3-dimensional network of cerebellar plasticity
Reference
C19931
Principal Investigator / Supervisor
Professor Nicholas Hartell
Co-Investigators /
Co-Supervisors
Institution
University College London
Department
Department of Pharmacology
Funding type
Research
Value (£)
199,804
Status
Completed
Type
Research Grant
Start date
07/01/2004
End date
06/01/2007
Duration
36 months
Abstract
Changes in transmission strength between synapses formed by granule cells and cerebellar Purkinje cells are thought to provide the cellular substrate for learning in the motor system. Both long-term depression (LTD) and long-term potentiation (LTP) can occur at the synapse and both forms of plasticity can spread beyond the activated synapses through the intercellular actions of the diffusible second messenger nitric oxide. In this proposal, we will examine the interactions between LTD and LTP in 3-dimensional networks of Purkinje cells that share common granule cell input and use novel imaging techniques to compare these effects with the spread of second messengers including calcium, nitric oxide and cyclic GMP.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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