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Molecular analysis of kdr and super-kdr resistance in recombinant Na channels of Drosophila melanogaster and rat

Reference	C19852
Principal Investigator / Supervisor	Professor Peter Norman Russell Usherwood
Co-Investigators / Co-Supervisors	Dr Ian Mellor
Institution	University of Nottingham
Department	Sch of Biosciences
Funding type	Research
Value (£)	199,908
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	30/06/2007
Duration	39 months

Abstract

The kinetic properties of wild-type and pyrethroid resistant (kdr and super-kdr) Na channels of Drosophila melanogaster expressed in Xenopus laevis oocytes will be investigated using single channel analysis and compared with those of wild-type and mutant rat IIA Na channels. The influence of the Type II pyrethroid deltamethrin on closed-state inactivation, activation, fast and slow inactivation and deactivation of these channels will be studied, particularly to test hypotheses on the sites and modes of action of deltamethrin on the insect and rat channels. These studies will provide novel information on the functional properties of the insect Na channel and its binding sites for pyrethroids that will be important for designing new insecticides.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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