BBSRC Portfolio Analyser
Award details
Biochemical Properties of the cytoskeletal protein talin
Reference
C19837
Principal Investigator / Supervisor
Professor David Critchley
Co-Investigators /
Co-Supervisors
Institution
University of Leicester
Department
Biochemistry
Funding type
Research
Value (£)
204,686
Status
Completed
Type
Research Grant
Start date
05/01/2004
End date
04/09/2007
Duration
44 months
Abstract
The cytoskeletal protein talin acts as a linker between the cytoplasmic domain of at least three classes of cell adhesion receptors (integrins, layilin, PECAM-1) and F-actin, and also provides a surface on which additional cytoskeletal and signalling components are assembled which affect the turnover of the adhesive complex. We propose (i) to establish whether all three adhesion molecules bind to the same or overlapping sites in the N-terminal talin FERM domain, and whether PIP kinase also competes for binding to this same region (ii) to characterise actin-binding site within the FERM domain (iii) to investigate the possibility that the vinculin sites in the talin rod are regulated by an intramolecular interaction within talin.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search