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Enzymology of Homologous Recombination

Reference	C19814
Principal Investigator / Supervisor	Prof. Malcolm White
Co-Investigators / Co-Supervisors	Dr Derek Richard
Institution	University of St Andrews
Department	Biology
Funding type	Research
Value (£)	237,478
Status	Completed
Type	Research Grant
Start date	01/10/2003
End date	30/09/2006
Duration	36 months

Abstract

Homologous Recombination (HR) is vital for DNA repair and the generation of genetic diversity. Archaeal HR is poorly understood but appears related to eucaryal HR. We have identified and cloned several proteins implicated in archaeal HR, including the Holliday junction resolving enzymes Hjc and Hje. We will continue our characterisation of their enzyme mechanisms and substrate recognition, and examine the protein:protein and protein:nucleic acid interactions using a variety of biophysical, biochemical and proteomic technologies. Our aim is to gain an understanding of this important pathway at a molecular level. The project builds on a great deal of previous work and a strong set of collaborative partnerships.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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