BBSRC Portfolio Analyser
Award details
Genetic and biochemical analysis of a novel Tat protein export pathway in the archaeon Halobacterium salinarum
Reference
C19762
Principal Investigator / Supervisor
Dr Albert Bolhuis
Co-Investigators /
Co-Supervisors
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
194,772
Status
Completed
Type
Research Grant
Start date
05/01/2004
End date
04/01/2007
Duration
36 months
Abstract
The Twin-arginine translocation (Tat) pathway, which has the unique ability to transport fully folded proteins, is involved in the transport of the majority of extracytoplasmic proteins in the halophilic archaeon Halobacterium salinarum. This is in stark contrast to most other organisms, which require the Tat pathway only for a small subset of proteins. Genome analysis clearly indicates that the halobacterial Tat-translocase is unique in terms of both composition and structure, and this project is aimed at: (i) genetic analysis of tat genes; (ii) purification of the translocase and determination of its subunit composition; and (iii) analysis of the mechanism of Tat-dependant transport through the development of in vitro translocation assays.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search