BBSRC Portfolio Analyser
Award details
The roles of Rab38 and Rab32 in melanosome biogenesis
Reference
C19747
Principal Investigator / Supervisor
Professor Miguel Seabra
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Div of Biomedical Sciences
Funding type
Research
Value (£)
216,623
Status
Completed
Type
Research Grant
Start date
01/09/2003
End date
31/10/2006
Duration
38 months
Abstract
Melanosomes are an excellent model for studying the biology of lysosome-related organelles. We propose to investigate the role of Rab38 and the closely related Rab32 in melanosome biogenesis. We will examine if the differential localisation of melanosomal Rabs (Rab27 and Rab38/32) to distinct subpopulations of melanosomes is correlated with different organelle maturation stages. Biochemical characterisation of Rab38 mutants, and the study of melanosomal protein trafficking in cells expressing dominant negative forms of Rab38/32, or cells treated with silencing RNA oligos, should give insight into their functional roles. Identification of interacting proteins as candidate effectors will help determine the molecular basis of Rab38/32 function.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search