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The function of the endosomal aspartic proteinases cathepsin D and E in the immune system
Reference
C19711
Principal Investigator / Supervisor
Professor Benny Chain
Co-Investigators /
Co-Supervisors
Institution
University College London
Department
Immunology and Molecular Pathology
Funding type
Research
Value (£)
232,941
Status
Completed
Type
Research Grant
Start date
11/05/2004
End date
10/07/2007
Duration
38 months
Abstract
Cathepsin D and E are homologous aspartic proteinases, found within the endosomal system of the cell, but with quite distinct intracellular and tissue distributions. The function of both enzymes remains unclear. Both enzymes are expressed prominently within cells of the immune system. The project will analyse the activity of proteolytic pathways of cells of the immune system in vitro, and the function of the immune system in vivo, in mice whose haematopoietic systems have been made deficient in one or both of these enzymes by targeted homologous recombination. Identification of the major functions of these proteinases is a first essential step in being able to relate the function of these enzymes to their structure.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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