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The role of the Sec1p-like/Munc18c protein Vps45p in SNARE complex formation
Reference
C19548
Principal Investigator / Supervisor
Professor Nia Bryant
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
School of Life Sciences
Funding type
Research
Value (£)
187,652
Status
Completed
Type
Research Grant
Start date
01/10/2003
End date
30/09/2006
Duration
36 months
Abstract
Several families of proteins are involved in membrane fusion events throughout evolution, ranging from yeast to mammalian cells. These include the SNARE, Rab and Sec1p-like/Munc18 (SM) families of proteins. The SM protein Vps45p functions, in conjunction with the SNARE complex consisting of TIg2p, TIg1p, Vti1p and Snc2p, and the Rab protein Vps21p, to control membrane fusion in the endocytic system of the yeast Saccharomyces cerevisiae. Experiments described here build on my previously published studies and aim to understand the regulation of the SNARE complex formation using a combination of yeast genetics and biochemistry.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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