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Regulation of neuronal P2X-purinoceptor trafficking and function
Reference
C19497
Principal Investigator / Supervisor
Dr Ruth Murrell-Lagnado
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Pharmacology
Funding type
Research
Value (£)
179,824
Status
Completed
Type
Research Grant
Start date
01/05/2003
End date
31/10/2006
Duration
42 months
Abstract
The regulated trafficking of ionotropic receptors into and out of the plasma membrane provides a mechanism for rapidly modulating synaptic currents. We have shown that P2X2 and P2X4 purinoceptors heterologously expressed in neurones act presynaptically to enhance the release of glutamate and yet they display dramatically different trafficking behaviours. P2X4 undergoes rapid internalisation and recycling, whereas P2X2 is stable at the plasma membrane. Our aim is to understand the regulation of P2X receptor trafficking and function, the role of receptor cycling in determining the response to ATP and the contribution of individual P2X subunits and in determining how the surface expression of heteromeric receptors is modulated.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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