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Functional analysis of the cytoplasmic domain of CD31(PECAM-1) in regulating leucocyte signalling and migration

Reference	C19491
Principal Investigator / Supervisor	Professor Christopher Buckley
Co-Investigators / Co-Supervisors	Professor Eric Jenkinson, Professor Gerard Nash, Professor Michael Salmon
Institution	University of Birmingham
Department	Immunity and Infection - Rheumatology
Funding type	Research
Value (£)	252,592
Status	Completed
Type	Research Grant
Start date	01/04/2003
End date	01/04/2006
Duration	36 months

Abstract

The ability to act both as an activatory and inhibitory molecule and the presence of discrete phosphorylation sites within distinct modules in its cytoplasmic domain, suggests that CD31 mediated signalling is regulated by differential associations with cytoplasmic signalling adaptors. We propose to establish the molecular connection between patterns of tyrosine, serine and threonine phosphorylation in the cytoplasmic domain of CD31 and key biological processes such as leucocyte activation, migration and apoptotic cell clearance. We will also generate new monoclonal reagents to identify specific phosphorylated residues in CD31 as well as confirm the in vivo relevance of our finding using mutant/chimaeric mice.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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