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The functional roles of conventional myosins during neuronal growth cone motility
Reference
C19453
Principal Investigator / Supervisor
Professor Peter Duncan Chantler
Co-Investigators /
Co-Supervisors
Institution
Royal Veterinary College
Department
Veterinary Basic Sciences - London
Funding type
Research
Value (£)
244,920
Status
Completed
Type
Research Grant
Start date
01/04/2003
End date
30/06/2006
Duration
39 months
Abstract
Neuronal growth cone movement underlies the development and maintenance of the mammalian nervous system. The conventional myosin isoforms, IIA and IIB, have been implicated in this dynamic process in which they display separate but linked functions. While we have shown that myosin IIB is required for neurite outgrowth and myosin IIA is involved in cell adhesion, our understanding is incomplete and key questions remain. Which isoform is responsible for neurite retraction or retrograde actin flow? Do separate rho and rac upstream pathways regulate myosins IIA and IIB? What are the functional states of cellular myosins? These questions will be answered using functional knockouts of cultured neurones in combination with overexpression studies.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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