Award details

Using forced evolution molecular modelling and bioinformatics to understand and exploit plant CYP74s

Reference	C19396
Principal Investigator / Supervisor	Professor Rod Casey
Co-Investigators / Co-Supervisors	Professor Stephen Bornemann, Dr Marcus Durrant, Dr Shirley Ann Fairhurst
Institution	John Innes Centre
Department	Metabolic Biology
Funding type	Research
Value (£)	183,796
Status	Completed
Type	Research Grant
Start date	01/07/2003
End date	30/06/2006
Duration	36 months

Abstract

CYP74 cytochrome P450s (CYP74s) are key enzymes in the synthesis of plant oxylipins, chemicals that play important roles in food, agricultural, chemical and flavour/fragrance industries. This proposal aims to gain better understanding of their catalytic mechanisms and activities, including new substrate and product specificities, through forced evolution, molecular modelling/bioinformatics and site-directed mutagenesis of sequences from plant genomes. Such advances will provide new understanding on the mechanisms and specificities of CYP74s that can be used to produce new biocatalysts and new oxylipins with potential as green plant protectants, flavours, fragrances and chemical feedstocks.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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