BBSRC Portfolio Analyser
Award details
Cell cycle regulation by MDM2: a combined proteomic and molecular investigation
Reference
C19313
Principal Investigator / Supervisor
Professor Mark Boyd
Co-Investigators /
Co-Supervisors
Dr Nikolina Vlatkovic
Institution
University of Liverpool
Department
Cancer Studies
Funding type
Research
Value (£)
178,612
Status
Completed
Type
Research Grant
Start date
16/06/2003
End date
15/06/2006
Duration
36 months
Abstract
MDM2 regulates disparate cellular events ranging from p53 homeostasis to Beta-adrenergic receptor internalisation. Moreover, MDM2 promotes G1-S progression by both p53- dependent and independent mechanisms. This proposal focused on the p53-independent pathway/s. To examine this we sought and identified MDM2 binding proteins that might mediate MDM2s effects and thus discovered MTBP. MTBP is a strong candidate target for MDM2s p53-independent cell cycle effects. We will use proteomic technology to characterise novel MTBP interacting proteins and also additional MDM2 interacting proteins to delineate the pathways in which each of these molecules function. We will also examine MDM2-MTBP interactions using molecular approaches.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search