Award details

ER modelling protein flow and transfer at the ER-Golgi interface

Reference	C19286
Principal Investigator / Supervisor	Professor Christopher Hawes
Co-Investigators / Co-Supervisors	Professor Federica Brandizzi
Institution	Oxford Brookes University
Department	Faculty of Health and Life Sciences
Funding type	Research
Value (£)	215,852
Status	Completed
Type	Research Grant
Start date	01/09/2003
End date	28/02/2007
Duration	42 months

Abstract

Controversy exists around the exact nature of the exit sites on the plant endoplasmic reticulum, that feed material to the Golgi apparatus. We have hypothesised the existence of direct connections that exist between ER and Golgi and that the actomyosin system is responsible for movement of Golgi, of exit sites and for the modelling of the cortical ER network. This programme will utilise a range of GFP constructs combined with photobleaching technology and expression of mutant proteins to identify and test the role of the cytoskeleton in ER and Golgi movement, to identify and characterise the dynamics of ER exit sites and to quantify protein flow in the ER membrane. The activity of the ER-Golgi continuum during the cell cycle and mitosis will also be assessed.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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