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Regulation of membrane protein trafficking in axons by commissureless
Reference
C19246
Principal Investigator / Supervisor
Professor Guy Justin Clive Tear
Co-Investigators /
Co-Supervisors
Institution
King's College London
Department
GKT School of Medicine
Funding type
Research
Value (£)
227,236
Status
Completed
Type
Research Grant
Start date
01/08/2003
End date
30/11/2006
Duration
40 months
Abstract
Proteins must be sorted to their appropriate compartment in the cell for normal function. Recently intracellular trafficking has been identified as a mechanism for gene regulation, proteins can be moved from their first functional compartment to silence activity. Addition of ubiquitin to proteins has emerged as a reversible mechanism to signal protein transport between locations. We have identified that Commissureless (Comm) harnesses the ubiquitination pathway to prevent the Roundabout receptor (Robo) reaching the cell surface during axon outgrowth in Drosophila. Here we propose experiments to identify further factors involved in this process, the nature of the Comm/Robo interaction and the role of ubiquitin ligase Nedd4.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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