BBSRC Portfolio Analyser
Award details
Enzymatic activity of a mono-haem c-type cytochrome. Cytochrome c' is a nitric oxide reductase
Reference
C19243
Principal Investigator / Supervisor
Professor James Moir
Co-Investigators /
Co-Supervisors
Institution
University of York
Department
Biology
Funding type
Research
Value (£)
181,472
Status
Completed
Type
Research Grant
Start date
20/10/2003
End date
19/03/2007
Duration
41 months
Abstract
In previous BBSRC-funded work we demonstrated that the bacterial mono-haem cytochrome c from Rhodobacter capsulatus possesses a nitric oxide reductase activity. NO detoxification is required in diverse biological environments, and cytochrome c is widely distributed among the proteo-bacteria. In this project we will express and purify cytochrome c and its putative electron donor protein CybP from R. capsulatus in order to develop a biochemical assay for NO reduction by this system, characterise the enzymological properties of cytochrome c and measure the products of NO reduction. Also, we will investigate the enzymatic properties of the cytochrome c from pathogenic bacterium Neisseria meningitidis.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search