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Biochemical analysis of agonist at G protein coupled receptors
Reference
C19232
Principal Investigator / Supervisor
Professor Philip Gordon Strange
Co-Investigators /
Co-Supervisors
Institution
University of Reading
Department
Animal and Microbial Sciences
Funding type
Research
Value (£)
201,100
Status
Completed
Type
Research Grant
Start date
29/09/2003
End date
28/09/2006
Duration
36 months
Abstract
This project aims to understand the biochemical basis of agonist action for the D2 dopamine receptor by defining the individual steps in G protein activation that are regulated by different agonists. The D2 receptor will be expressed in insect cells together with different G proteins and assays for G protein activation (GTP binding and dissociation, GDP release, ternary complex breakdown, GTP hydrolysis) applied to this system with a range of agonists. The study will provide entirely novel information relating to the variation in relative efficacy for a range of agonists based on biochemical differences in their mechanisms of action. The findings will be of direct relevance to drug design.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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