Award details

Molecular characterization of neuronal GRIF-1: a new trafficking molecule?

Reference	C19144
Principal Investigator / Supervisor	Professor Frances Stephenson
Co-Investigators / Co-Supervisors
Institution	University College London
Department	Dept of Pharmaceutical and Biological Ch
Funding type	Research
Value (£)	244,268
Status	Completed
Type	Research Grant
Start date	01/05/2003
End date	01/05/2006
Duration	36 months

Abstract

In contrast to excitatory glutamatergic synapses there is a paucity of molecular information regarding the composition, architecture and regulation of inhibitory synapses. My laboratory has discovered and cloned a novel 913 aa protein, GRIF-1, GABA-A Receptor Interacting Factor-1, by virtue of its specific association with GABA-A receptor beta2 subunits. Experimental and bioinformatics information support a role for GRIF-1 as a trafficking molecule in excitable tissues. This proposal aims to delineate the function of this novel gene by identifying associated proteins, refining the subcellular distribution of GRIF-1 and studying the effects of GRIF-1 on GABA-A receptor function, assembly, receptor internalisation, and cell surface expression.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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