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NMDA receptor-mediated dendritic protein synthesis a potential mechanism for the regulation of synaptic strength
Reference
C19143
Principal Investigator / Supervisor
Professor David Wyllie
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Neuroscience
Funding type
Research
Value (£)
227,664
Status
Completed
Type
Research Grant
Start date
01/10/2003
End date
30/09/2006
Duration
36 months
Abstract
The best cellular model of learning and memory is long-term potentiation (LTP). Late-LTP, LTP lasting for an hour or more, requires the production of new proteins. Recent research indicates that the protein synthesis machinery needs to be active at the time of LTP induction, even though the functional readout of protein- dependent LTP is observed much later. Such early protein synthesis may occur at dendritic, rather than somatic, sites by the translation of pre-existing messenger RNAs at these synaptic sites. This proposal will investigate the role of local nRNA translation as a regulator of NMDA receptor-dependent LTP in hippocampal slices using a combination of molecular biological and electrophysiological techniques.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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