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Award details
Identification of DNA elements regulating replication in mammalian cells
Reference
C19018
Principal Investigator / Supervisor
Professor Iain Morgan
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
Veterinary Pathology
Funding type
Research
Value (£)
162,936
Status
Completed
Type
Research Grant
Start date
01/07/2003
End date
30/06/2006
Duration
36 months
Abstract
Human papillomavirus (HPV) encoded E1and E2 are essential for replication of the viral genome; they recognise the viral origin of replication and act as the initiation complex. Using a novel quantitative PCR assay for detection of E1 and E2 mediated replication, developed in the lab, this proposal will identify DNA elements in the viral genome that regulate DNA replication. This will be done using a series of deletion and mutation studies. The results will be of interest to a wide range of scientists working on HPV and DNA replication in general and will also assist in the development of HPV based vectors to be used in gene therapy, as well as providing potential targets for disruption of the viral life cycle.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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