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Function of multidomain protein Eps 15 in Drosophila endocytosis
Reference
C19002
Principal Investigator / Supervisor
Professor Cahir O'Kane
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Genetics
Funding type
Research
Value (£)
249,728
Status
Completed
Type
Research Grant
Start date
27/06/2003
End date
26/06/2006
Duration
36 months
Abstract
Endocytosis is important in many processes including signal transduction and synaptic vesicle recycling. Many proteins have now been implicated in it, whose functions are poorly understood. Here we focus on Eps15, a multidomain protein proposed to have a key role in organising several of the steps of endocytosis. We have identified two mutant alleles of the Drosophila gene, and our data suggest an endocytic phenotype. We will characterise their phenotypes using microscopy and electrophysiology, and study the biochemistry of the protein. Rescue of mutant phenotypes by Eps15 transgenes will allow us to assess the roles of individual domains, motifs, and biochemical properties of the protein in its endocytic function.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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