Award details

Construction of a well differentiated cell line from human corneal endothelium

Reference	C18995
Principal Investigator / Supervisor	Professor Richard Faragher
Co-Investigators / Co-Supervisors	Dr Marcus Allen
Institution	University of Brighton
Department	Sch of Pharmacy & Biomolecular Sciences
Funding type	Research
Value (£)	249,644
Status	Completed
Type	Research Grant
Start date	01/05/2003
End date	31/07/2007
Duration	51 months

Abstract

Study of the basic biology of the human cornea is currently hindered by a shortage of donor material. A unique layer of cells, the corneal endothelium, is responsible for the maintenance of corneal clarity. Cell lines derived from human endothelium would overcome problems of tissue supply and allow progress in areas ranging from the most basic to the more applied. The applicants seek support to produce immortal cell lines from the endothelium through the introduction of such telomerase and p16 insensitive CDK4, to assess the differentiation state of such lines through a range of functional assays and finally to produce conditionally immortal variants of such lines.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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