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Elucidating the role of key residues in channel formation and gating of inward rectifier potassium channels (Kir2.0)

Reference	C18892
Principal Investigator / Supervisor	Professor Peter Stanfield
Co-Investigators / Co-Supervisors	Professor Michael Sutcliffe
Institution	University of Warwick
Department	Biological Sciences
Funding type	Research
Value (£)	187,652
Status	Completed
Type	Research Grant
Start date	01/08/2003
End date	31/07/2006
Duration	36 months

Abstract

Inward rectifier potassium channels are important physiologically, setting resting potentials and contributing to action potential repolarisation and K ion homeostasis. These channels are gated by intracellular polyamines binding to certain acidic residues. Our evidence shows other residues to be additionally involved, the gating process having some similarities with N-type inactivation in Kv channels. We shall identify pore lining residues involved in the binding of polyamines at the site at which they block permation in Kir2.1. We shall also investigate parts of the channel N- and C terminus, including individual residues, that interact to form the inner pore mouth and the first bind polyamines in Kir2.1, 2.2 and 2.3.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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