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Award details
Integration of the JNK and IKK signalling pathways by JIP scaffold proteins
Reference
C18835
Principal Investigator / Supervisor
Dr Alan Whitmarsh
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
184,194
Status
Completed
Type
Research Grant
Start date
14/07/2003
End date
13/04/2006
Duration
33 months
Abstract
The JNK MAP kinase signalling pathway responds to stress signals and is implicated in the regulation of multiple cell processes, in particular cell death. JNK activity can be regulated by scaffold proteins of the JIP family. The IKK pathway is a major cell survival pathway. IKK beta phosphorylates JIP family proteins leading to the down-regulation of JNK signalling. The objective of the project is to determine the role of JIP scaffold proteins in integrating the JNK and IKK signalling pathways to determine cell fate. The sites of IKK beta phosphorylation on JIP proteins will be identified and the effect of IKK beta phosphorylation of JIPs on the formation of scaffold complexes and on JIP and JNK-mediated apoptosis will be determined.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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