Award details

Cellular responses to reductive stress

Reference	C18801
Principal Investigator / Supervisor	Professor Christopher Grant
Co-Investigators / Co-Supervisors
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	210,768
Status	Completed
Type	Research Grant
Start date	20/05/2003
End date	20/05/2006
Duration	36 months

Abstract

An increasingly important area of research is based on sulphydryl chemistry, since oxidation of -SH groups is one of the earliest observable events during oxidant-mediated damage and -SH groups play a critical role in the function of many macromolecular structures including enzymes and membrane proteins. Whilst much is known regarding the effects of oxidation on redox homeostasis, little is known regarding the consequences of a reducing environment. The aim of this research project is to characterise the cellular responses to reductive stress using the model eukaryote Saccharomyces cerevisiae. In particular, we will determine the cellular targets which are damaged by reductive stress and identify the defence mechanisms which protect against a reducing environment.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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