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Characterisation of the role in cytokinesis/cell separation of novel cytoskeletal components in budding yeast
Reference
C18794
Principal Investigator / Supervisor
Dr Clive Price
Co-Investigators /
Co-Supervisors
Institution
Lancaster University
Department
Biological Sciences
Funding type
Research
Value (£)
203,028
Status
Completed
Type
Research Grant
Start date
05/05/2003
End date
04/06/2006
Duration
37 months
Abstract
We will characterise the cytoskeletal functions of two S. cerevisiae genes, YPR171w and SYP1, identified as suppressor of the cytokinesis defective iqg1-1 mutation. Using a combination of genetic, biochemical and microscopy techniques we will define the role of these genes during cytokinesis and organisation of the cortical actin cytoskeleton. The phenotype of null mutations and possible synthetic interactions will be carefully examined with respect to cytoskeletal function. Protein and protein interactions and the localisation pattern of the two proteins will be monitored with particular emphasis on cell cycle changes and dependency relationships between Ypr171w, Syp1 and other previously characterised proteins; Iqg1, Hof1, Sla1, Rvs167.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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