Award details

leptin modulation of GABAa receptor function: a novel process for regulating hippocampal excitability

Reference	C18771
Principal Investigator / Supervisor	Dr Jenni Harvey
Co-Investigators / Co-Supervisors	Professor Jeremy Lambert
Institution	University of Dundee
Department	College of Life Sciences
Funding type	Research
Value (£)	164,052
Status	Completed
Type	Research Grant
Start date	01/05/2003
End date	30/06/2007
Duration	50 months

Abstract

In the CNS inhibitory fast synaptic transmission mediated by GABAA receptors is one of the main determinants of neuronal excitability. In this study we will be investigate the cellular mechanisms underlying leptin facilitation of GABAergic function in the hippocampus. As PI 3-kinase is a key component of both leptin receptor signalling and GABAA receptor trafficking processes, the effects of leptin on GABAA receptor expression will be examined. The role of the cytoskeleton in leptin action will also be addressed as PtdIns(3,4,5)P3 binds to key cytoskeletal proteins and may influence GABAA receptor expression. The mechanisms involved may represent a novel process for controlling hippocampal excitability.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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