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Control of CD80 and CD86 expression during dendritic cell maturation: implications for tolerance and autoimmunity
Reference
C18735
Principal Investigator / Supervisor
Professor David Sansom
Co-Investigators /
Co-Supervisors
Dr Yong Zheng
Institution
University of Birmingham
Department
Medical Sciences - Medicine
Funding type
Research
Value (£)
226,872
Status
Completed
Type
Research Grant
Start date
01/02/2003
End date
01/02/2006
Duration
36 months
Abstract
Within the immune system, T lymphocytes must distinguish between foreign material and the bodys own tissues. This decision takes place during T cell interactions with dendritic cells (DCs). We propose that two DC proteins (CD80 and CD86) which bind to both stimulatory (CD28) and inhibitory (CTLA-4) receptors on T cells can influence this process via differential expression. The control of CD80 and CD86 expression is not understood. We will examine the transcriptional and posttranslational controls of these proteins in DCs during in vitro differentiation and maturation and address the influence of immunomodulatory cytokines on these processes.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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