BBSRC Portfolio Analyser
Award details
Investigating if SI-induced actin disruption is involved in programmed cell death
Reference
C18649
Principal Investigator / Supervisor
Professor Vernonica E. (Noni) Franklin-Tong
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
217,288
Status
Completed
Type
Research Grant
Start date
09/08/2003
End date
08/08/2006
Duration
36 months
Abstract
We have two separate events identified as being triggered in incompatible pollen: (1) programmed cell death and (2) sustained actin depolymerisation. The data suggest that these events may be linked. Animal cell studies suggest that F-actin depolymerisation acts as an executor of apoptosis. The aim of this proposal is to ascertain if this is the case; i.e. Is the actin depolymerisation and PCD linked by a common signalling cascade? Briefly, we wish to answer these interlinked questions: (A) Is F-actin depolymerisation an effector and executor of PCD in pollen? (i.e. is this required for PCD to initiate and or progress?) (B) Are caspase-like modification (e.g. cleavage) of actin and ABPs triggered? (i.e. are these actin cytoskeleton-based targets for PCD?).
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search